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<span style="font-family: "><p class="MsoNoSpacing" style="text-align: justify; margin: 0cm 0cm 0pt;"><span style="mso-ansi-language: EN-US;" lang="EN-US"><span style="font-size: small;"><span style="font-family: Calibri;">In modern agriculture, the use of agrochemicals has grown considerably, increasing production cos
Summary: Few therapies target the loss of tumor suppressor genes in cancer.We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes.The endosomal sorting complexes required for transport (ESCRT) ATPases VPS4A and VPS4B score as strong synthetic